TBL Group 10 - E-Team Based Learning’s Updates
Murder Mystery Application Problem 2
The ER physician sent a sample of John’s blood to a commercial lab to be tested for poisoning. Upon getting this result, Dr. Jones starts John on bicarbonate, glucose, and an ethanol drip.
Why was the ethanol IV drip used?
- A. To compete with ethylene glycol for acetaldehyde dehydrogenase.
- B. To compete with ethylene glycol for alcohol dehydrogenase.
- C. To compete with ethylene glycol for transport across the blood brain barrier.
- D. To compete with ethylene glycol for transport across the renal tubules.
- E. To provide reducing equivalents for detoxifying ethylene glycol.
- F. Methyl-malonyl-CoA mutase deficiency
INSTRUCTIONS:
- Draft your response in the comment area below. Your answer should illustrate your thought process in as much detail as possible. Post your response once you have a complete explanation of your reasoning. Do not refresh your browser until you have posted your comment. We recommend a minimum of 5 sentences for an adequate explanation.
- Now refresh your browser. Read and comment on the responses of others from your team. Suggest extensions or modifications to their ideas. Refresh your browser regularly to view and respond to new comments from your team. Be sure to comment on all the other members of your team using the @Name function, with reasoned, evidence-based argument (several sentences per comment at least). Comment on comments as you think necesary and helpful. Work towards an agreed group response through this online chat.
- Your team reporter should now enter your team's answer in Benware. The whole-class discussion of this application exercise will take place verbally as usual.
Awesome. And just to clarify, the elevated ketones (acetone) would be due to the buildup of NADH from the ethylene glycol metabolism right?
Alright sweet. Thank you!
Correct!
I submitted B
Yeah, treatment with either fomepizole or ethanol can be used to compete for ADH to inhibit toxic metabolite production.
So this doctor is treating this baby for methanol poisoning? I think ethanol is used to compete for alcohol dehyrogenase, so B
Definitely ethylene glycol poisoning
I think its B because ethanol would act as a competitive inhibitor of alcohol dehydrogenase.
I would say B even though Fomepizole seems like a better option than getting this baby drunk.
LOL completely agree
Can't remember if it's A or B, but I think its alcohol dehydrogenase... so B