TBL Group 10 - E-Team Based Learning’s Updates

Application Problem 2

A woman is a balanced carrier of a Robertsonian translocation involving chromosomes 14 and 21. Her husband is chromosomally normal. They have two children: a daughter who is a balanced translocation carrier and a son with translocation Down syndrome. Given below are genotypes for a polymorphic marker on the long arm of chromosome 21.

Mother: [1,2]

Father: [2,2]

Balanced carrier daughter: [1,2]

Translocation Down syndrome son: ?

Based on the genotypes given for three family members, which of the following predicts the genotype of the translocation Down syndrome son?

A. 1,1

B. 1,2

C. 2,2

D. 1,1,2

E. 1,2,2

INSTRUCTIONS:

  1. Draft your response in the comment area below. Your answer explanation should illustrate your thought process in as much detail as possible. Post your response once you have a complete explanation of your reasoning. Do not refresh your browser until you have posted your comment.
  2. Now refresh your browser. Read and comment on the responses of others from your team. Suggest extensions or modifications to their ideas. Refresh your browser regularly to view and respond to new comments from your team. The product of your team discussion should be an answer choice (to enter in Benware) and a well-reasoned justification for the answer your team chooses.
  3. Your team reporter should now enter your answer in Benware and the whole-class discussion of this application exercise will take place verbally as usual.

 

  • Brett Drake
  • Isaac Ngo
  • Morgan Powers
  • Ilse Mejia
  • Isaac Ngo
  • Morgan Powers
  • Salil Bhole
  • Ilse Mejia
  • Brett Drake
  • Ilse Mejia
  • Morgan Powers
  • Morgan Powers
  • Brett Drake